This self-adhering scrapbook contains a blend of illustrated and non-illustrated clippings from various printed sources (newspapers, periodicals, books, etc.), originating mostly from New England in the 1860s-1890s. Topics include religion, politics (American and British), the assassination of U.S. President James A. Garfield (1831-1881), health and wellness, eulogies, and other articles. The volume is bears the printed manufacturers label "Mark Twain's Scrap Book Registered April 23rd. 1878 . . . Published by Slote, Woodman & Co."
A selection of topics represented in the scrapbook include:
- Material relating to religion (primarily Christianity, but also Islam, Mormonism, etc.). Some clippings are derogatory towards non-Christian groups or peoples. Enclosed is an issue of Our Prison Missionary (Vol. II, Dec. 1890, no.2), a publication from the Christian Aid Association "devoted to Christian work in penal institutions." Hymns, religious poetry, baptism, and Martin Luther's will (page 56) are also present.
- Politically related clippings include stories about the U.S. Congress and senators, the British House of Parliament, Queen Victoria, Lincoln's Gettysburg Address, and General Grant's illness. Many of the volume's pages are dedicated to the assassination of President James A Garfield, with updates on the President's health after he was shot (page 33). Additional clippings with messages from world leaders expressing their sympathies, information about Vice President Chester A. Arthur, and the background of President Garfield's assassin Charles J. Guiteau.
- Health and wellness-related content ranges from life advice, the dangers of children eating snow, mental health, vaccination, and more. An issue of the Land of Hope Review includes a brief article warning "juveniles" of the danger of smoking tobacco.
- Eulogies for President Garfield, Henry Wadsworth Longfellow, and other "In Memoriam" articles and hymns are spread throughout the volume. A music sheet of a song called "Rest, Sweetly Rest" (credited to a publication called The Watchword is noted as being suitable for the death of a scholar.
An advertisement for the scrapbook itself includes information and prices about other variations of "Mark Twain's Self Adhering Scrap Book," such as a druggists' prescription book, a child's scrapbook, and a pocket scrapbook.
