The Latin America collection is made up of 57 volumes of miscellaneous items related to New Spain, Mexico, Peru, and Guatemala. The items span from 1518 to 1882. The materials came to the Clements Library from multiple dealers and donors between 1928 and 1951. The New Spain series is made up of volumes that broadly cover the areas under Spanish control in Latin America. The Mexico, Peru, and Guatemala series is made up of materials that specifically address each of those areas. Topics addressed in the letters and documents include laws, religious doctrines, indigenous culture and interactions with Europeans, city ordinances, land holdings, viceregal matters, and many other subjects. Of particular note is a 1760 manuscript copy of a 1587 original of three religious dramas in the Nahuatl language. In 2023, an 1822 contemporary manuscript copy of Manuel de la Barcena's Manifiesto al Mundo: La Justicia y Necesidad de la Independencia de Nueva-España was added to Volume 38.
In addition to this finding aid, the Clements Library has created detailed the following descriptions of each volume in the collection: Latin America Collection: Volume Descriptions.