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The Native American collection contains miscellaneous letters and documents concerning Native American Indians in the United States, Canada, and the West Indies, and their interactions with British and American settlers.

The Native American collection is comprised of approximately 125 miscellaneous letters and documents concerning Native American Indians in the United States, Canada, and the West Indies, and their interactions with British and American settlers (1689-1921). Topics range from land agreements, legal issues, treaties, descriptions of travel through Indian Territory, Indian uprisings and conflicts, Indian captivities, prisoners of war, Indian enslavement, and interactions with Quaker and Moravian missionaries. Tribes include the Cherokee, Choctaw, Chickasaw, Cree, Iroquois, Ojibwa, Oneida, Ottawa, Kickapoo, Seneca, Shawnee, Sioux, among others, and concern activities in Canada, New England, the Midwest, the South, and the western frontier. Also present are items written in Cherokee, Mohawk, and Ojibwa.

This collection is made up of letters that Connecticut teacher and lawyer Sheldon Moore received from friends and family members in the early 19th century. Several acquaintances discussed life in New Haven, Connecticut, and his sister, Eliza Langdon, described her life in Mobile, Alabama.

This collection is made up of 14 letters that Connecticut teacher and lawyer Sheldon Moore received from friends and family members from 1824-1863. Early letters from acquaintances in New Haven, Connecticut, include their comments on book prices and recommendations for materials for Moore's personal or professional use. After 1835, Moore's sister Eliza wrote about her life in Marion and Mobile, Alabama. She often reported on health issues, such as outbreaks of scarlet fever and cholera, and discussed political and social news. During the 1850s, she commented on local attitudes about disunion and abolition. The final item is a letter to Sheldon Moore from James Richardson of the United States Sanitary Commission (April 18, 1863).