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The William and Isaac Perkins papers contain correspondence written between brothers William Lee Perkins and Isaac Perkins, 1784-1794, concerning politics, their careers, and family news.

The William and Isaac Perkins papers contain 18 letters written between brothers William Lee Perkins and Isaac Perkins, of Ashford, Connecticut, and Kingston upon Thames, England. Their correspondence, written from 1784 to1794, frequently touched on politics, including a fairly long account of Shays' Rebellion (January 25, 1787), mention of the Constitutional Convention (May 28, 1787), and speculation by William on the chances of a reunion between the United States and Great Britain (May 14, 1787).

Also present are comments on Loyalists, the national debt, and news concerning their families and careers. In his letter dated April 4, 1788, William Lee Perkins commented on his medical writing, including attempts at "arranging and distinguishing diseases, which I am contributing my poor Endeavours to introduce in this Country." He also gave medical advice in several letters.