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The Chronological Files Series is the larges series in the collection and consists of documents from HIV/AIDS-related conferences, meetings and other events, as well as periodic reports. The series is subdivided by year of reports or events, with each year grouping further divided into Events and Reports. Early years in HIV/AIDS discovery (1980s) have been combined into a single more expansive subseries. Each year section is subdivided into Events and Reports. The Events sections correlate with international conferences (International Conference on AIDS and Conference on Retroviruses and Opportunistic Infections being the most prevalent in the collection) while Reports correlate with annual reports by a range of organizations (e.g. United Nations).

The Communications series (57.1 MB, 2008-2009) contains materials produced by and about the Cockrel administration, with talking points and speeches related to the opening of a new Census Bureau office, cable commission, Spring Clean Up and Detroit Recycles, and the 2009 State of the City Address as well as articles about Mayor Ken Cockrel's transition and performance, op-ed pieces and news releases produced by the Mayor's office, and snapshots of various pages on the mayor's website as it appeared in 2008-2009. Also includes campaign materials and April 2009 poll results.

The Community Activism series, 1981-2003, documents Mary Hathaway's involvement with a number of peace and social justice organizations in the Ann Arbor area and is further divided into the subseries: Coalition for Arms Control (CAC), Coalition Against War in the Gulf, Economic Conversion Task Force, Interfaith Council for Peace and Justice, Shelters, and the What is National Security Forum.

The Cornelia C. Hampton series includes a typescript reminiscence, "A Story of the South During the Civil War Days and the Harrowing Experiences of Mrs. C.C. Hampton, Mother of Will E. Hampton and the Outrages Suffered at Hands of the Texas Secessionists." The story, recorded by Will Hampton based on recollections of his mother, describes the experiences of Carlos and Cornelia Hampton in Hunt County, Texas during the years 1858-1862, the pressures on Dr. Hampton to enlist in the Confederate army and Cornelia's journey back to Michigan in 1862. Will E. Hampton originally took down her story in shorthand and later printed it in his paper, the Charlevoix Courier. There are also three poems by Cornelia Hampton.

The Correspondence series (1 linear foot and 12.0 GB, 1943-2012) includes both original and digitized versions of documents and is divided into three subseries: Family correspondence, Personal correspondence, and Research correspondence. Family correspondence contains letters and related materials sent or received by Lawrence Witt's mother, Gladys Collins. The bulk of the correspondence was sent by Witt himself, and much of that from when he was a prisoner of war (POW) in Germany. Also included are notifications sent by the Department of War about Witt's status, a few notes or letters to Witt, and related materials such as newspaper clippings. Personal correspondence primarily consists of letters sent between Lawrence Witt and his future wife, Lois Davis, but also includes a few letters from other friends and acquaintances. The bulk of this subseries was sent following the end of the war. The Research correspondence subseries contains letters related to Laura Edge's research on her father's and other airmen's experiences as prisoners of war in Germany during World War II.

Nearly 300 letters written to his wife while he was serving in Company B, 19th Michigan Infantry (1862-1865). He is concerned with folks and affairs at home. He comments on guard and picket duty; the officers (especially General McClellan); the Chaplain; the health of the men, deaths and burials; the draft, deserters and Negroes coming into camp; on rumors of battles; and speculates about the end of the war. He tells about boxes and mail from home; explains why he is fighting; and writes often of the ever present food problem. There is an account of a fierce battle near Franklin with a cavalry unit of Bragg's army in which his brother is killed and the regiment captured and marched south to Libby Prison. He tells an interesting story about buckets of burning leather being carried through the camp to smoke out smallpox. Paroled, the men marched or rode in hog cars back to Fortress Monroe and Annapolis where he was hospitalized for a while. After being at home for a short time, he returns to the regiment, and the march south to Atlanta begins. He describes their camps and shanties; trading with rebel pickets; prisoners taken (including a woman in man's clothing); a Sunday in camp with "preaching in one place, firing of guns in another, a brass band playing in another place, and cooking meat and washing clothes most all around you." He visits the Chickamauga battlefield, describes the destruction and evacuation of Atlanta; the march to Savannah; the capture of a rice mill and the burning of towns and plantations along the way through South Carolina. Finally the war is over. He is sent to McDougall Hospital in New York Harbor, and discharged May 26, 1865.

The Correspondence series includes personal letters (both the original letters and typescripts) between members of the Bingham and Warden families. There is extensive correspondence (1848-1861) between Bingham and his wife, Mary Warden Bingham, during his absences while serving in government offices in Lansing, Michigan and Washington, D.C. There is also a substantial correspondence from James W. Bingham, writing to his parents during his boarding school years at the Normal School in Ypsilanti, Michigan and one year while studying at the University of Michigan in Ann Arbor. Later letters between James and his mother were written while James was serving with Co. H, 1st Michigan Infantry, and then in Co. B, 2nd Battalion, 16th U.S. Infantry. Also of interest are letters in 1850 referring to John, a nephew who participated in the California Gold Rush, where he died.