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The collection is comprised of annual reports, brochures and pamphlets, programs, proposals, and reports from the Department of Internal Medicine. This includes publications from subunits and related clinics such as the Frankel Cardiovascular Center, the Committee on Medical Ethics, the Division of Molecular and Human Genetics, the Division of General Medicine, and the Medical Center.

The Department of Internal Medicine Publications contains two series, Unit Publications and Sub-Unit Publications. The Unit Publications series contains printed material published specifically by the Department of Internal Medicine. These publications are defined as being widely distributed and may be published at regular intervals. They are arranged by genre of the publication. The Sub-Unit Publications series contains publications from subordinate offices, departments, programs and organizations within the Department of Internal Medicine. These publications are arranged alphabetically by the creating sub-unit.

The Michigan Medicine (University of Michigan) publications contain materials from University Hospital, University Hospitals, University of Michigan Medical Center (UMMC), University of Michigan Health System (UMHS), C. S. Mott Children's Hospital, and the Women's Hospital. The publications include annual reports, bylaws, brochures, manuals, directories, reports, newsletters, and websites dealing with different aspects of the health system including administration, development, facilities, marketing and outreach, nursing, and services.

The Michigan Medicine publications contain materials from University Hospital, University Hospitals, University of Michigan Medical Center (UMMC), and University of Michigan Health System (UMHS). Though "University Hospitals" is an entity which has existed in the past and does exist concurrently with UMMC and UMHS, it is not treated here as a sub-unit, because it is often used interchangeably with "Medical Center" or "Health System" on publications.

The publications of the Medical School (part of the Health System) and the academic and research departments of the Health System (such as the Department of Surgery and the Department of Pediatrics and Communicable Disease) are held in separate publications groups.

The publications collection consists of nine series. Six series deal with different aspects of the health system: Administration, Development, Facilities, Marketing/Outreach, Nursing Services, and other Services. Two series deal with additional hospitals within the University Health System: C. S. Mott Children's Hospital and Women's Health (Women's Hospital). An additional series contains an archived copy of the Michigan Medicine website.