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Irish Quakers and compatriots of William Penn, the family of John Holme prospered in the new colony of Pennsylvania. The Holme family account book includes accounts of goods sold and services rendered to Philadelphia families in the 1680s and 1690s. Interspersed throughout are medicinal and food preparation receipts, mostly recorded in the 1740s, as well as copies of the laws of Pennsylvania, ca. 1685, the wills of Capt. Thomas Holme, 1695, and John Holme, Jr., and a poem and two religious songs.

The Holme account book is particularly heterogeneous in its construction. It includes accounts of goods sold and services rendered to Philadelphia families in the 1680s and 1690s. However, the accounts appear to have been kept by several different members of the family. These include records of the sale of shoes, gun powder, grain, cloth, nails, and many other goods. Interspersed throughout the accounts are pages of calculations, numerous medicinal receipts, and receipts for various food preparations (including a large number relating to wine), most of which appear to have been recorded in the 1740s, though some are earlier.

John Holme, Sr., also appears to have used the "account book" to copy the laws of Pennsylvania (copied ca.1685), and he or a later Holme recorded the wills of Capt. Thomas Holme (1695; William Penn's Surveyor General), and of one of the John Holmes, probably John Holme, Jr. Finally, a poem and two religious songs have been included, the former perhaps written by one of the Holmes. It is tempting to attribute the poem to John Holme, Sr., whose poetry is among the earliest recorded as having been written in the province (see Pennsylvania Magazine of History and Biography, vols. 3 and 20).

Medicinal receipts are indexed under the term "Receipts" while those for foods are indexed as "Cookery." Additional indexing (e.g. for type of food or medicine) is highly selective. Similarly, only the primary names are indexed for the accounts.

The Quaker Collection consists of miscellaneous letters, diaries, and documents relating to the religious and social history of the Society of Friends in America during the 18th and 19th centuries.

The Quaker collection consists of miscellaneous letters, diaries, and documents related to the religious and social history of the Society of Friends in America during the 18th and 19th centuries. These items offer insights into Quaker's daily activities and concerns, such as family life, education, and attending meetings, as well as their participation in various social reform movements, such as abolition, treatment of Native Americans, prison improvements, temperance, and pacifism. The collection also documents internal divergences of American Quakerism in the 19th century, particularly the social and doctrinal disputes that culminated in the Hicksite and Wilburite schisms.

• 1707: A manuscript copy of the death warrant of William Leddra, the last of four Quakers (including Mary Dyer) executed in Massachusetts Bay colony for their religious beliefs
• July 26, 1755: A letter from Alexander Colden to Sir William Johnson voicing frustration with Quakers who refuse to support the war effort in Pennsylvania, and an announcement of General Braddock's defeat
• August 4-12 and 17, 1761: Two accounts, one by an anonymous woman, of Quaker presence at Treaty negotiations held at Easton, Pennsylvania, between the government of Pennsylvania and the Six Nations tribes. Discussed are the negotiations, Quaker-Indian interactions, and the role of Quaker women in the Society
• [After 1770]: An account by an anonymous author of a conference with Native Americans, mostly of the Minnisink Tribe
• October 13, 1829: A letter from Phoebe Post Willis of Jericho, New York, to Isaac Post on the death of John Hicks and strife between Orthodox and Hicksite Quakers
• March 10, 1843: A letter from Ethan Foster of Westerly, Rhode Island, to Thomas B. Gould on Wilburite-Gurneyite strife in his local meeting, and the disownment of Wilbur
• [After 1863 July]: A letter describing a meeting between Abraham Lincoln and five Quaker prisoners of war, who had been forced into the Confederate army, captured by the Union, and held at Fort Delaware
• Various dates: Reports, minutes, and epistles from yearly friends meetings in America and Great Britain