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Letters from relatives in New York, New Jersey and Iowa discussing in part plans to migrate westward; letter, 1852, recounting missionary life in India; Civil War letters from Townsend M. Luce (Co. F., Third Michigan Infantry), Rufus Cheney (Co. D, 2nd Michigan Cavalry), Charles O. Reed (probably Co. A, 4th Michigan Cavalry), Philip Segur (Co. A, 7th Michigan Cavalry), and one tentatively identified as Albert H. Freeman (Battery B, 1st Michigan Light Artillery); and miscellanea.

Professor of homoeopathic medicine at University of Michigan, mayor of Ann Arbor, Michigan, dean of the New York Homeopathic Medical College and director of Flower Hospital, New York City Commissioner of Public Health, and Democratic U. S. Senator from New York, 1923-1938. Personal and medical correspondence, speeches, scrapbooks containing food and health articles, photographs, and other papers concerning his medical and political interests. Correspondents include: Calvin Coolidge, Herbert Hoover, Eleanor Roosevelt, Franklin D. Roosevelt, and Alfred E. Smith.

The Royal Copeland collection, consisting primarily of correspondence, speeches and writings, scrapbooks, and articles, relates primarily to Copeland's medical career as professor of homeopathic medicine at the University of Michigan, dean of the New York Homeopathic Medical College and Flower Hospital, and New York City Commissioner of Public Health, and as United States Senator.