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The Amos A. Evans collection is comprised of 3 volumes: a "Prescription book of the U.S. Frigate Constitution," also known as "Old Ironsides" (1812); a "Daily Report of Cases in the Marine Barracks at the Navy Yard" at Charlestown, Massachusetts (1813); and a "Reefer's Log" written by Evan's son, Alexander Evans, during a trip from Maryland to Boston in 1833. These volumes provide an overview of the health of seamen aboard an American warship in 1812, along with the medical treatments of the day.

The Amos A. Evans collection is comprised of 3 volumes: a 266-page "Prescription book of the U.S. Frigate Constitution" (March 26-August 27, 1812); a 17-page "Daily Report of Cases in the Marine Barracks at the Navy Yard" at Charlestown, Massachusetts (1813); and a 33-page "Reefer's Log" written by Evan's son, Alexander Evans, during a trip from Maryland to Boston in 1833. The collection also contains 8 loose documents, located in the back of volume 1, including hospital expenditures, a medical supply inventory for the Constitution, and notes on the crew of the Independence.

Volume 1, entitled "The Daily Prescription Book on Board the Frigate Constitution," contains records of the daily treatments Evans prescribed for his patients, providing an overview of the health problems of seamen aboard a United States warship on the Atlantic coast during the War of 1812. Evans listed both in-patient and out-patient visits for each day, and recorded their names, complaints, diagnoses, and treatments. The most common entries relate to sexually transmitted diseases (often gonorrhea and syphilis), with diarrhea (gastroenteritis) being the next most common. Other complaints include delirium, opium overdose, epileptic convulsions and coughing up blood. In accord with the advice of Dr. Rush, Evans treated vomiting with an emetic, ipecac; diarrhea with a laxative, castor oil; and other complaints with bleeding, blistering and poultices. On average, Evans listed about 30 patient visits per day.

Evans witnessed the Constitution's encounter with the British ship, Guerrière, on August 19, 1812, one of the first sea battles of the War of 1812. Evans described in detail the injuries and treatment of five crew members and two officers wounded during the battle (pages 255-263).

1. March 6, 1813: An inventory of medicine, instruments, and supplies for the Frigate Constitution.
2. December 10-23, 1815: Expenditures of hospital food stores, signed S.D. Townsend.
3. January 7-20, 1816: Expenditures of hospital food stores, signed by S.D. Townsend.
4. January 16, 1816: Receipt of goods for the ship Independence.
5. January 25-27, 1816: A medical report and autopsy on the treatment and death of William Oaty, who suffered as a result of the accidental discharge of a pistol.
6. [1816]: A report on damages to the Independence.
7. [1816]: Copy of accounts to George Bates for supplies for the Independence.
8. April 9, 1846: A copy of a report from Evans to Commander Christopher Morris stating that John Wentworth was wounded on board the Constitution, on August 10, 1812. Evans also described his treatment of the injury.

Volume 2 is entitled "Daily Report of the Cases in the Navy Yard at Charleston." Covering from August 7-16, 1813, and spanning 17 pages, Evans recorded his treatments for cases of syphilis, gonorrhea, other venereal diseases, drunkenness, diarrhea, dysentery, scurvy, infections, coughs, injuries, and other ailments. Evans wrote down the name, symptoms, and treatment for each patient, and gave each a case number. He sometimes noted rank and whether or not the patient was a marine.

In the back of the book is a single case history of a man who punctured his lung from fractured ribs sustained from a fall off a wagon (July 18, 1818). Despite Dr. Evan's treatment of drawing more than five pints of blood over the ensuing five days, the patient recovered and was able to walk five miles by the end of the month. By this time, Dr. Evans had returned to private practice in Elkton, Maryland.

Scattered throughout the largely-blank interior of the book are six brief entries on plant and flower classification. These notes were written in a different hand and one entry is dated 1850.

Volume 3 is a 33-page travel log, entitled "A Reefer's Log," written by Alexander Evans, and addressed to his father, Amos Evans (September 7, 1833). Alexander Evans described his trip from the family home in Maryland to Boston by steamship and buggy, with stops along the way in Delaware, Pennsylvania, New Jersey, New York, Connecticut, and Rhode Island. Evans wonders at the improvements in travel: "it is no longer necessary for one who goes from city to city to make his will...what used to be an immense journey 100 years ago[,] vis. From Maryland to Boston[,] but now is no more than a hop skip and jump" (page 1). He also described architecture, terrain, and people he encountered during the journey. In Boston, several old friends of his father's showed him the navy yard and the surrounding towns. Evans reported on the layout of the Charlestown navy yard as well as the interiors of the Constitution and the Independence (pages 10-11). He also toured a paper mill and wrote about the machinery in the factory (page 19). He visited Noah Webster (page 16), attended a Harvard commencement (page 25), and listened to a Boston glee club (page 20).