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The Charles Caldwell lectures are manuscript notes taken by an observer of Caldwell's medical lectures - most likely in Lexington, Kentucky in 1825.

The manuscript lectures in this collection are unsigned, but are circumstantially attributed to Caldwell on the basis of internal references to a 30 year career in medicine, including an association with the Pennsylvania Hospital, to experience and research in pestilential epidemics, and to the author's "timely investigation of the sanguiniferous system." The manuscript probably represents a student's notes taken during a series of Caldwell's lectures in about 1825. They are not in Caldwell's hand.

The lecture series represented by this manuscript comprises an introductory course in medicine, covering nutrition, blood and the circulatory system, pathology, the nervous system, etc. Of particular interest are lectures on dreams, pleasure, memory and understanding, and differences between the sexes