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The George and José Bill papers contain essays, lectures, notes, prescriptions, and correspondence related to the medical practices of George Bill and his son, José Penteado Bill, of Harrisburg, Pennsylvania. Much of the material relates to unconventional medical practices and to topics in metaphysics. The collection also holds a series of astrological charts and notes.

The George and José Bill papers contain essays, lectures, notes, prescriptions, and correspondence related to the medical practices of George Bill and his son José Penteado Bill, of Harrisburg, Pennsylvania. The Correspondence and Documents series holds material related to George E. Bill's medical practice, including several letters written to his son during the 1920s. In one letter, he encouraged his son to avoid surgery for his granddaughter Audrey, and instead offered a dietary cure (February 1, 1922); in other letters, he discussed a "rhythometer" and the use of electricity as a medical cure.

The Essays, Lectures, Notes, and Speeches series is divided into several subseries. An unknown author compiled the Miss Doubleday gynecology notes while attending a lecture by Miss Doubleday; the notes include diagrams.

The Lectures on metaphysics consist of 13 lectures delivered by George Bill between November 2 and December 16, 1912, predicated upon a Law of Correspondence, "a General Law underlying the behavior of all Matter and the Spirit of Matter" (November 7, 1912). He mentioned magnetism, toxins thought to affect thoughts, and the polarity between elements of life (light, heat, and electricity) and death (darkness, cold, and magnetism), between which existence resides (November 6, 1912).

A series of Astrology charts and notes contains several charts copied from the work of Karl Anderson, as well as manuscript essays and projections.

Additional Essays, Lectures, Notes and Speeches concentrate primarily on medical topics, and most often concern pseudo-scientific conjectures and treatments outside the realm of conventional medicine. The series contains published articles as well as typed and manuscript drafts; some topics are hypnotism, the medical uses of electrical current, the human subconscious and its role in medicine, infrared therapy, and mental toxins and antitoxins.

A large number of Retained copies of prescriptions showcase a variety of medical treatments ordered by the Bills throughout the late-19th and early-20th century, including both conventional and homeopathic treatments.

The José Penteado Bill papers contain an assortment of material, including, but not limited to, scientific and medical notes, as well as a printed roster of the Massachusetts Chiefs of Police Association (July 1947). Other items are a traveling journal compiled in 1917 and a document giving Bill's grades from his second year of study at Harvard Medical School (1912). The Diaries subseries includes a partially-filled diary of José P. Bill from 1910, as well as a 1924 diary chronicling medical appointments; the latter was obtained in France and contains supplemental information in French. The Notes and notebooks subseries contains notes on José Penteado's engagements, patients, and prescriptions. Also included is a prescription notebook and pad.

The Printed Items series holds seven items. These are Keeley's Secrets, a publication on theosophy written by Mrs. Bloomfield Moore, with manuscript annotations (July 10, 1888); two medical journals; a scientific article; a pamphlet entitled "The Policy and Purpose of the Harrisburg Republican Club" (1902); a portion of an examination given to doctors at Clark University about "Diseases and Cures in Childhood" (December 1896); and a card on medicines, poisons, and antidotes. George Bill wrote the article, "The Relation of Hypnotism to the Subconscious Mind" (New York Medical Journal, May 1, 1897), an article entitled "Some Considerations Relative to the Therapeutic Application of the Electrical Current" (New York Medical Journal, November 13, 1897), and "The Conductivity of Human Radio-Activity" (Journal of the Allied Medical Associations of America, August 1919).

The Poems and Blank Stationery series contains pieces of blank stationery from Dr. George E. Bill's office in Harrisburg, PA, as well as two poems.

This collection is primarily made up of typescripts of letters that Dr. James M. Holloway wrote to his wife Anne while serving as a Confederate Army surgeon during the Civil War. Additional materials include typescripts on 19th-century medicine and clippings including full-color illustrations, from The Philadelphia Inquirer (1959-1961).

This collection (0.25 linear feet) is made up of typescripts related to Dr. James M. Holloway's service as a Confederate Army surgeon during the Civil War, typescripts related to 19th-century medicine, and illustrated newspaper clippings related to United States Army uniforms, national coats of arms, and Philadelphia, Pennsylvania, during the Civil War.

The bulk of the collection consists of Typescripts, including approximately 121 letters that Holloway wrote to his wife Anne on January 7, 1861, and from July 25, 1861-September 5, 1864. His earliest letters recount his experiences as a surgeon with the 18th Mississippi Infantry Regiment in Virginia, including his treatment of the wounded from the Battle of Ball's Bluff. Holloway, who took pride in his medical career, occasionally described specific patients, including amputees, a woman whose head had become detached from her body, and a dead soldier he dissected. He continued to write about his medical work after being promoted to the command of the hospitals of Richmond, Virginia, in 1862, and also discussed other aspects of his life there, such as the cost of food and other goods. Holloway expressed his devotion to the Confederate cause, and his early letters refer to his commitment to Christianity, which he maintained throughout the remainder of his correspondence. Some of Holloway's letters refer to the movements of Union and Confederate troops in Virginia and the western theater, the possibility of European intervention, specific battles, and the general progress of the war. By the fall of 1864, he feared that Richmond would be cut off from the rest of the Confederacy. In one late letter (written after the Emancipation Proclamation), he advised his wife to sell a female slave.

Holloway wrote 3 letters to his wife in May 1865, expressing his fear that the North would seek retribution from Southerners; he also reported that Beverly Tucker's home had been searched as a result of his suspected connection to the Lincoln assassination. In August and October 1865, Holloway wrote 3 letters to his wife from Louisville, Kentucky, primarily about local churches. Holloway's Civil War correspondence is followed by typescripts of his presidential address to the Tri-State Medical Society (or Mississippi Valley Medical Association) regarding current medical and surgical advancements and the increasing popularity of homeopathy (1882), a partial article about the history of medical education in the South (undated), and an obituary for Samuel Wilcox Warren (January 1878). He wrote 2 additional letters from Amsterdam, Netherlands, and Berlin, Germany, in September 1898, regarding his observations of local hospitals and medical procedures.

The Printed Items series (4 items) contains 3 full-color inserts from issues of The Philadelphia Inquirer, including photographs of toy soldiers wearing historical United States Army uniforms (July 5, 1959); a map of Civil War-era Philadelphia showing the locations of military camps and hospitals (July 5, 1959); a photograph of the coat of arms of the United Kingdom (February 7, 1960); and an editorial commemorating the centennial of the Star of the West incident (January 9, 1961).