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The Jacob Butler Varnum papers contain letters and documents related to Varnum's career as a factor at United States Indian trading posts in Sandusky, Ohio, and Fort Dearborn, Chicago; as a captain in the 40th Massachusetts Infantry during the War of 1812; and as a Washington D.C. merchant after he left government service. Included are letters and instructions from government officials concerning trade with Indians, as well as letters from Varnum to his father, Senator Joseph B. Varnum, concerning his activities as factor.

The Jacob Butler Varnum papers (79 items) contain letters and documents related to Varnum's career as a factor at United States Indian trading posts in Sandusky, Michilimackinac, and Fort Dearborn, Chicago; as a captain in the 40th Massachusetts Infantry during the War of 1812; and as a Washington D.C. merchant after he left government service. The collection is comprised of 59 letters, 1 diary, 13 documents and financial records, and 5 miscellaneous items. Included are letters and instructions from various government officials concerning trade with Indians in Ohio, Michigan, and Illinois, as well as five letters from Varnum to his father Senator Joseph B. Varnum (ca.1751-1821) concerning his activities as factor.

The Correspondence series (60 items) comprises the bulk of the collection. Forty-nine items document Varnum's governmental career spanning 1811 to 1826, during his service as Indian trade factor in Sandusky, Michilimackinac, and Chicago; and as captain of the 40th Massachusetts Infantry during the War of 1812. Varnum received instructions from various Indian agents and government officials concerning the regulation of trade with the Munsee, Ojibwe (Chippewa), Ottawa, Sioux, and Wyandot Indians, among others. Many letters came from the United States Office of Indian Trade at Georgetown, including four from Indian Officer John Mason (1812 and 1815), and 21 letters from Superintendent of Indian Trade Thomas Loraine McKenney (1816-1822). These contain discussions of trade operations, types of merchandise, questions arising about the sale of goods, and instructions for the reporting of financial accounts. Also of note are five letters from Varnum to his father, Joseph Bradley Varnum (1750-1821), in which he described his experiences at Sandusky and at Michilimackinac, as well as with the business of the trading house at Chicago (December 3, 1811; January 14, 1812; May 21, 1816; November 3, 1817; March 1, 1818).

• August 8, 1811: Joseph Bradley Varnum to John Mason, accepting the appointment of his son as agent of the United States Indian trading house at Sandusky, Ohio
• March 1, 1818: Varnum to his father predicting the outbreak of a great war with the Indians "from the Simenoles to the Sioux"
• February 8, 1820: Thomas L. McKenney letter to Jacob B. Varnum, giving instructions about the handling of money given to Varnum by Government Indian agents

Most of the 1823-1826 material concerns government reimbursements for military expenses at Fort Dearborn. The collection contains 11 letters documenting Varnum's post-governmental career as a merchant in Washington D.C. and Petersburg, Virginia (1826-1860).

• February 1827-August 1832: Five items regarding Varnum and John Biddle concerning mutual business interests in Detroit
• December 17, 1833: John H. Kinzie to Varnum concerning Chicago lands owned by Kinzie, a fur trader

The Diary series (1 item) contains a 26-page notebook with Varnum's description of his trip from Chicago to Dracut, Massachusetts, by way of Detroit and Buffalo (August 17-October 22, 1822), and from Detroit through New York and Philadelphia, to Washington D.C. (May 28-June 22, 1823). Varnum reported on his manner of travel (horse, ship, steamboat) and his travel route, describing stops at many of the major towns along the Erie Canal. He commented on the towns that he passed through including Rochester, New York, which had grown considerably since the opening of the Erie Canal (page 6). He also noted prices for room and board. The final five pages contain financial accounts for Varnum's military expenses incurred from 1813 to 1815.

The Documents and Financial Records series (13 items) contains material documenting Varnum's finances and his service in the War of 1812.

• June 8, 1813: Affidavits (and a fragment of the same item) documenting the capture of Joseph B. Varnum's trunks, taken by the British as they were being transported from Michilimackinac to Detroit
• 1814: Six military district orders related to promotions, responsibilities, and discipline in the 40th Massachusetts Infantry, in which Varnum was a captain under Acting Adjutant General George P. Peters
• August 22, 1815: Copy of a bond oath signed by Varnum as factor for Indian trade at Chicago, and a copy of his father, Jacob Butler Varnum's oath of office
• 1816-1827: Four financial records of debts and receipts for goods purchased by Varnum
• Undated [1808]: Deposition of Richard Smyth regarding the sale of a lot in Detroit owned by Varnum's father-in-law John Dodemead

The Miscellaneous series (5 items) contains 3 envelope covers, one of which includes a recipe for a "Lazy Daisy" cake (c.1930). Also present are a photograph of a man and two women outside of a tent next to a car (c.1930), and a typed 13-page biography of Joseph Bradley Varnum, undated and unattributed.

The Josephus Stuart papers contain correspondence, diaries, and documents related to Stuart's early medical practice and his service with the 29th regiment of the United States Infantry. The collection also includes a series of diaries written by Stuart between 1815 and 1821, which document Stuart's service as chancellor to the U.S. Consulate in London, a visit to former president Thomas Jefferson at Monticello in 1816, and Stuart's experiences operating a steamboat.

The Josephus Stuart collection contains 34 letters, dated 1810-1834, the majority of which belonged to Stuart, though six letters are addressed to Gerrit Wendell, a Washington county judge and former member of the New York state senate. In addition, the collection contains 38 documents, nine of which are associated with Stuart's father-in-law, Enoch Leonard. Several of the papers deal with Stuart's early medical practice, including a letter regarding research related to Stuart's medical thesis, which was a defense of cutaneous absorption. Other documents concern Stuart's military service with the 29th regiment, United States Infantry, including his commission as paymaster, signed by President James Madison.

Of primary significance are Stuart's eight diaries, written from 1815 to 1821. The early diaries document Stuart's period as chancellor to the U.S. Consulate in London. He records the sea voyage, as well his observations of English life and customs, often unfavorably comparing them with his views on conditions in America. The diaries also record trips Stuart took to Ireland, Scotland, France, and the Netherlands; he took care to note his observations during his travels, including the landscape, sights, lifestyle, living conditions, economy, and politics. Diaries four and five recount Stuart's return to the United States and include a detailed account of his visit with Thomas Jefferson at Monticello on December 24 and 25, 1816. He recorded Jefferson's views on a wide variety of topics, and made notes on his appearance and home. Also contained within diary five are accounts of Stuart's role as agent for Francis Cazeau, James Monroe's inauguration, travels to Ohio, encounters with Native Americans, and various business transactions, including his steamboat venture. The next several diaries record his experiences running the Walk-in-the-Water, his marriage to Ann Leonard in May 1818, and the beginning of his financial troubles in 1819. In the last diary (#8), Stuart had settled in Jamesville, New York, as an attorney. The last month of the diary records the loss of the steamboat, which ran aground during a gale in 1821.

Also included in the collection are a set of architectural plans by noted New York architect Philip Hooker. Hooker designed a house for Stuart in 1818, which was apparently never built; the plans are contained within a small booklet. The Stuart papers also have eleven items related to family genealogy, and three 1810 New York newspapers.

The Samuel Huntington papers contain letters and documents of a prominent Ohio settler and political leader. Included are items on his business, political, and military activities.

The Samuel Huntington papers (60 items) contain letters and documents of a prominent Ohio settler and political leader. The Correspondence and Documents series contains 23 letters and 27 documents and financial records. Many of the early items are records and receipts for sales of land and legal services. Other documents include an agreement for Elija Gunn to build a fence around Huntington's home (November 10, 1804), a transfer of land in Cleveland Township from Huntington to Augustus Gilbert (May 4, 1808), Huntington's payment receipt for his services to the Ohio Militia (May 24, 1813), and numerous other land transactions.

• A letter from fellow Ohio settler David Bryant asking for investments to buy a still for whiskey making (August 28, 1801)
• A letter from Turhand Kirtland, Connecticut Land Company agent, inquiring about the companies' interests in settling new towns (March 27, 1802)
• A second letter from Kirtland discussing politics and congratulating Huntington on his election as Trumbull County delegate to the constitutional convention (March 3, 1803)
• A congratulatory letter from William Law on Huntington's election as state governor accompanied by a number of state policy requests (December 18, 1808)
• A personal letter from Samuel Huntington to his eldest son, Francis, that describes his travels through Cincinnati, including an Indian attack, and provides instructions to his son for handling the tax collector (July 3, 1813)

Items related to the military include four Quartermaster documents from Detroit and Washington (August 11, 1813-July 16, 1814), and Samuel Huntington's letter to Simon Huntington of Grand River, Ohio, in which he discussed his opinions on the War of 1812 (December 14, 1814). The collection concludes with a farewell letter and religious diatribe from the dying 86-year-old Moses Lyman, a prominent citizen of Goshen, Connecticut.

The Account Book series consists of a 23-page booklet of "Copies of Notes and other Obligations due to me with their Indorsments" (1795-1814). These notes record large transactions (most between $70 and $1,000 with one as high as $4,716.96), and provide details on reasons for the deals and the parties involved.

The Photographs and Newspaper Clippings series holds one of each item. The clipping is undated and likely from a local Cleveland newspaper. The clipped article is "Colonel Samuel Huntington Surveys his Property" by S.J. Kelly, about Huntington's early property holding in Cleveland. The photograph is unlabeled but is possibly a painted portrait of Huntington.